Functional interaction of CFTR and ENaC in sweat glands
نویسندگان
چکیده
منابع مشابه
Regulation of endogenous ENaC functional expression by CFTR and ΔF508-CFTR in airway epithelial cells.
The functional expression of the epithelial sodium channel (ENaC) appears elevated in cystic fibrosis (CF) airway epithelia, but the mechanism by which this occurs is not clear. We tested the hypothesis that the cystic fibrosis transmembrane conductance regulator (CFTR) alters the trafficking of endogenously expressed human ENaC in the CFBE41o⁻ model of CF bronchial epithelia. Functional expres...
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A method has been worked out for the measurement of the volume of sweat produced by individual glands. A special paper, impregnated with iodine, absorbs water in a uniform way and shows the area of wetting by a sharply defined blue dot. Indirect calibrations showed that 1 cm.(3) of water would form a spot of 700 cm.(2) area, and that this relation of volume to area was a constant one over a wid...
متن کاملCorrection: In vivo readout of CFTR function: Ratiometric Measurement of CFTR-Dependent Secretion by Individual, Identifiable Human Sweat Glands
In the ‘‘Drug Delivery and Imaging of C-sweating’’ section of the Materials and Methods the drug concentrations are listed incorrectly. The correct concentrations should be described as follows: ‘‘The same site was then re-injected within 2 min with a cocktail of 280 uM atropine, 160 uM isoproterenol and 20 mM aminophylline dissolved in lactated Ringers to make a final injection volume of 0.1 m...
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To assess CFTR function in vivo, we developed a bioassay that monitors and compares CFTR-dependent and CFTR-independent sweat secretion in parallel for multiple (~50) individual, identified glands in each subject. Sweating was stimulated by intradermally injected agonists and quantified by optically measuring spherical sweat bubbles in an oil-layer that contained dispersed, water soluble dye pa...
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BACKGROUND AND OBJECTIVES Hyperhidrosis is a condition that affects a large percentage of the population and has a significant impact on peoples' lives. This report presents a technical overview of a new noninvasive, microwave-based device for creating thermolysis of sweat glands. The fundamental principles of operation of the device are presented, as well as the design and optimization of the ...
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ژورنال
عنوان ژورنال: Pflügers Archiv - European Journal of Physiology
سال: 2007
ISSN: 0031-6768,1432-2013
DOI: 10.1007/s00424-006-0182-2